Convicts Frank Morris and Clarence Anglin have washed ashore in San Francisco after surviving their infamous escape from Alcatraz Federal Penitentiary in June 1962. They soon meet their gruff and disappointed handler, a mysterious young woman who’s also running from something, and hope to quickly get their way north to the border – if they can even make it out of Modesto alive. As a dogged federal manhunt and chance encounters threaten the desperate convicts, everyone involved is about to discover the same bloodstained truth: life on the run is an even more hellish prison than Alcatraz could have ever been.